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Review paper discussing the pathological hallmarks, clinical parallels, and value for drug testing in Alzheimer’s disease of the APP[V717I] London transgenic mouse model; also touching on reMYND’s other proprietary transgenic mouse models (Tanghe et al., 2010).

Published 02 January 2013 | By reMYND

Notwithstanding the vast amount of resources invested into discovery and development of new targets and treatments, Alzheimer’s disease (AD) remains an indication with enormous unmet needs. One complicating factor for successful drug development is the unknown etiology of idiopathic AD. AD entails noxious aggregation of β-amyloid (Abeta) and Tau, representing fundamental processes in disease onset and progression

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Review paper discussing the pathological hallmarks, clinical parallels, and value for drug testing in Alzheimer’s disease of the APP[V717I] London transgenic mouse model; also touching on reMYND’s other proprietary transgenic mouse models (Tanghe et al., 2010).